Poly(glycoamidoamine)s: Cationic glycopolymers for DNA delivery

Cationic Polybutyl Cyanoacrylate Nanoparticles for DNA Delivery

To enhance the intracellular delivery potential of plasmid DNA using nonviral vectors, we used polybutyl cyanoacrylate (PBCA) and chitosan to prepare PBCA nanoparticles (NPs) by emulsion polymerization and prepared NP/DNA complexes through the complex coacervation of nanoparticles with the DNA. The object of our work is to evaluate the characterization and transfection efficiency of PBCA-NPs. T...

Cationic microparticles: A potent delivery system for DNA vaccines.

An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection. The microparticles released intact and functional DNA over 2 weeks in vitro. In addition, the microparticles induced higher levels of marker gene expression in vivo. After i.m. immunization, the mi...

preparation and in vitro transfection of modified cationic liposome-linear polyethyleneimine-dna nanocomplexes for gene delivery

Cationic lipids and polymers for gene delivery

Gene therapy, aiming to eradicate causes rather than symptoms of diseases, is believed to be the therapy of the future. A new promising area for the application of gene therapy is the emerging field of regenerative medicine, where gene delivery can be used to enhance or modify cell functions in an organ/tissue or in engineered substitutes. The aim of gene therapy is to achieve the expression of...

Polysorbate cationic synthetic vesicle for gene delivery.

Synthetic nonionic surfactant vesicles (niosomes) are a colloidal system with closed bilayer structures, displaying distinct advantages in stability and cost compared with liposomes. In this article, polysorbate cationic niosomes (PCNs) were developed as gene carriers. The PCNs comprised nonionic surfactants (i.e., polysorbates) and a cationic cholesterol, and were synthesized using a film hydr...